Water (H2O) is the most abundant and important molecule of life. Natural water contains small amount of heavy isotopes.\r\nPreviously, few animal model studies have shown that the isotopic composition of body water could play important roles in\r\nphysiology and pathophysiology. Here we study the stable isotopic ratios of hydrogen (d2H) and oxygen (d18O) in human\r\nblood plasma. The stable isotopic ratio is defined and determined by dsample = [(Rsample/RSTD)21] * 1000, where R is the\r\nmolar ratio of rare to abundant, for example, 18O/16O. We observe that the d2H and the d18O in human blood plasma are\r\nassociated with the human renal functions. The water isotope ratios of the d2H and d18O in human blood plasma of the\r\ncontrol subjects are comparable to those of the diabetes subjects (with healthy kidney), but are statistically higher than\r\nthose of the end stage renal disease subjects (p,0.001 for both ANOVA and Student�s t-test). In addition, our data indicate\r\nthe existence of the biological homeostasis of water isotopes in all subjects, except the end stage renal disease subjects\r\nunder the haemodialysis treatment. Furthermore, the unexpected water contents (d2H and d18O) in blood plasma of body\r\nwater may shed light on a novel assessment of renal functions.
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